Released in Oncogene.

Certain colon cancer genes take a step back to move forward Recent Weizmann Institute studies are revealing a complicated picture of cancer progression where certain genes that get tumor growth in the earlier stages get suppressed in later stages – going for a step back to move forward. Released in Oncogene, current analysis from the the lab of Prof . Avri Ben-Ze’ev of the Section of Molecular Cell Biology shows that the tumor cells at the invasive entrance of later-stage human colorectal cancer may take a straight bigger step back: Some of their gene expression patterns are distributed to those of healthy intestinal stem cells.

Other findings of the medical position statement on medical diagnosis and management of CRC in IBD sufferers include: Disease duration, even more extensive disease, severity of inflammation, principal sclerosing cholangitis , and a positive genealogy of sporadic CRC are all associated with an elevated threat of developing CRC. Dysplasia detected on biopsy is currently considered the very best marker for CRC risk in IBD. Patients with IBD and a non-adenoma-like dysplasia-linked lesion or mass that does not lend itself to becoming completely removed by colonoscopy should be treated with colectomy .